Except for a few corner cases, as long as the “Delete replica when source file is removed” option is enabled, when you delete files or folders from your source, they are also deleted from the target.
Local volume or a network share target:
A deleted folder on your source will not be deleted from the target, unless you permanently delete it from the source i.e. empty the Recycle Bin.
Object storage target:
A folder moved to the Recycle Bin or permanently deleted is also deleted from the target, only if the whole volume is configured as a source. If the source is just a folder on a volume, the folder will not be automatically deleted from the object storage target and you have to manually delete it from within the target.